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KMID : 0043320170400060736
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Archives of Pharmacal Research
2017 Volume.40 No. 6 p.736 ~ p.745
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Collision-induced dissociation pathways of H1-antihistamines by electrospray ionization quadrupole time-of-flight mass spectrometry
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Do Jung-Ah
Noh Eun-Young
Yoon Soon-Byung
Lee Ji-Hyun
Park Sung-Kwan
Mandava Suresh
Baek Sun-Young
Lee Jong-Kook
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Abstract
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Over the past decades, mass spectrometry technologies have been developed to obtain mass accuracies of one ppm or less. Of the newly developed technologies, quadrupole time-of?flight mass spectrometry (Q-TOF?MS) has emerged as being well suited to routine and high-throughput analyses of pharmaceuticals. Dietary supplements and functional foods have frequently been found to be contaminated with pharmaceuticals. In our continuous efforts to develop methodologies to protect public health against adulterated dietary supplements, we have constructed a mass spectral database for 21 H1-antihistamines encountered as adulterants by using liquid chromatography-electrospray ionization (LC-ESI)/Q-TOF?MS, and have proposed their possible collision-induced dissociation pathways. This database will be very useful for the rapid and accurate detection of H1-antihistamines (known) and their analogues (unknown) illegally added to dietary supplements as well as in other sample matrices.
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KEYWORD
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H1-antihistamine, LC-ESI/Q-TOF?MS, Collision-induced dissociation, Dietary supplement
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